US Atopic Dermatitis Therapeutics Market Analysis

US Atopic Dermatitis Therapeutics Market Analysis


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The US Atopic Dermatitis Therapeutics Market was valued at US $5.166 Bn in 2022, and is predicted to grow at (CAGR) of 6.8% from 2023 to 2030, to US $8.744 Bn by 2030. The key drivers of this industry include the rising prevalence of Atopic Dermatitis (AD), innovative drugs in the pipeline and evolving healthcare landscape. The industry is primarily dominated by players such as Sanofi, AbbVie, Pfizer, Regeneron, Eli Lilly, Astellas among others.

ID: IN10USPH435 CATEGORY: Pharmaceuticals GEOGRAPHY: US AUTHOR: Riddhi Solanki

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US Atopic Dermatitis Therapeutics Market Analysis: Executive Summary

The US Atopic Dermatitis Therapeutics Market is at around US $5.166 Bn in 2022 and is projected to reach US $8.744 Bn in 2030, exhibiting a CAGR of 6.8% during the forecast period.

Atopic dermatitis, commonly known as eczema, is a persistent skin condition characterized by inflammation, redness, and irritation. It is non-contagious and can affect individuals of all age groups, although it frequently initiates in childhood. Key risk factors involve a history of eczema, allergies, hay fever, or asthma, and a familial predisposition to these conditions. Common symptoms encompass intense itchiness, redness, swelling, cracking, clear fluid discharge, crusting, and scaling. Treatment strategies for AD may involve routine moisturizing and other self-care practices, the application of medicated creams to manage itching and aid in skin repair, the administration of topical or oral medications, and additional therapies such as phototherapy or immunosuppressants. Several companies, including Sanofi, Pfizer, AbbVie, Leo Pharma, Eli Lilly, and Teva Pharmaceutical, produce therapeutic options for AD. Their product lines encompass topical corticosteroids, calcineurin inhibitors, and other medications aimed at alleviating the symptoms of atopic dermatitis.

It is estimated that currently, around 31 million Americans are living with AD, with an estimated prevalence of around 7.3%. The market is propelled by significant factors such as the surge in the prevalence of AD, a strong pipeline of innovative drugs, the evolving healthcare landscape, and consumer knowledge of the therapeutics industry. However, conditions such as poor adherence and treatment effectiveness, high cost of treatments like JAK inhibitors, market saturation, and others can restrict the growth and potential of the market.

The top market player, Sanofi, has recently obtained approval from the US FDA for its therapeutic Dupixent for the treatment of AD in children. It is followed by its close competitor, Pfizer.

US Atopic Dermatitis Therapeutics Market Analysis 2022 to 2030

Market Dynamics

Market Growth Drivers

Surge in the prevalence of AD: It is estimated that approximately 31.6 million Americans are currently living with some form of AD accounting to around 10% of US population. The overall prevalence of AD is 7.3% in the US. It is estimated that every 1 in 10 children in US will develop eczema in their life. The significant and expanding number of patients forms a robust demand for efficient therapeutic solutions. Elements such as urbanization, shifts in hygiene practices, and heightened exposure to allergens could play a role in the escalating prevalence.

Pipeline of Innovative Drugs: Pharmaceutical firms are proactively creating novel medications, particularly biologics with precise mechanisms of action, providing enhanced effectiveness and the potential for more extended periods of remission. This continual innovation is anticipated to attract a growing number of patients seeking treatment and generate enthusiasm within the market.

Evolving healthcare landscape: The rise of telemedicine and direct-to-consumer models is expanding access to specialized care and medications, potentially reaching populations that have been underserved. These changes in healthcare delivery have the potential to strengthen the market further by creating new pathways for patients to obtain AD therapeutics.

Market Restraints

Poor Adherence and Treatment Effectiveness: Although treatments address symptoms, they rarely provide a cure, necessitating prolonged usage and potentially resulting in medication fatigue and non-compliance. Regarding side effects, specific medications, especially systemic therapies, may pose potential adverse effects that could deter patients from following the prescribed treatment regimen.

High cost and low affordability: Innovative, focused treatments such as biologics are associated with substantial costs, restricting access for individuals with low incomes and potentially straining healthcare systems. Certain insurance plans may not include coverage for newer or specialized treatments, leaving patients with significant out-of-pocket expenses.

Market saturation: The greater prevalence of generic alternatives for older topical steroids and immunosuppressants may exert downward pressure on the prices of newer, more costly therapies. The market for topical corticosteroids and emollients is already saturated, posing a challenge for new entrants to distinguish themselves.

Notable Recent Updates

June 2022, The FDA has granted approval for Dupixent® (dupilumab) from Sanofi, marking it as the initial biologic medication authorized for children aged 6 months to 5 years with moderate-to-severe atopic dermatitis.

January 2022, Pfizer Inc. reported that the U.S. Food and Drug Administration (FDA) has granted approval for CIBINQO® (Abrocitinib), an oral, once-daily Janus kinase 1 (JAK1) inhibitor, designed for treating adults with refractory, moderate-to-severe atopic dermatitis (AD).

Healthcare Policies and Regulatory Landscape

The regulatory framework in the United States is overseen by the Food and Drug Administration (FDA), the primary health authority responsible for ensuring the safety and effectiveness of drugs and medical devices. The process of obtaining a license or drug approval in the U.S. involves several stages, including preclinical testing, clinical trials, FDA review, FDA approval, and post-market surveillance. The FDA thoroughly assesses the safety, efficacy, and quality data of the drug and may request additional information or studies. Following the review, the FDA makes a regulatory decision regarding the drug's approval, which is communicated to the manufacturer or sponsor. Post-approval, the FDA continues monitoring the safety and effectiveness of the drug through post-market surveillance activities.

This comprehensive process ensures that drugs marketed in the U.S. adhere to the necessary standards for safety, effectiveness, and quality. The regulatory environment for new therapeutics in the United States is evolving to accommodate the development and approval of novel treatments

Competitive Landscape

Key Players

  • Sanofi
  • Pfizer
  • AbbVie
  • Leo Pharma
  • Eli Lilly
  • Novartis
  • Teva Pharmaceuticals
  • Galderma
  • Regeneron Pharmaceuticals
  • Astellas Pharma

1. Executive Summary
1.1 Disease Overview
1.2 Global Scenario
1.3 Country Overview
1.4 Healthcare Scenario in Country
1.5 Patient Journey
1.6 Health Insurance Coverage in Country
1.7 Active Pharmaceutical Ingredient (API)
1.8 Recent Developments in the Country

2. Market Size and Forecasting
2.1 Epidemiology of Disease
2.2 Market Size (With Excel & Methodology)
2.3 Market Segmentation (Check all Segments in Segmentation Section)

3. Market Dynamics
3.1 Market Drivers
3.2 Market Restraints

4. Competitive Landscape
4.1 Major Market Share

4.2 Key Company Profile (Check all Companies in the Summary Section)

4.2.1 Company
4.2.1.1 Overview
4.2.1.2 Product Applications and Services
4.2.1.3 Recent Developments
4.2.1.4 Partnerships Ecosystem
4.2.1.5 Financials (Based on Availability)

5. Reimbursement Scenario
5.1 Reimbursement Regulation
5.2 Reimbursement Process for Diagnosis
5.3 Reimbursement Process for Treatment

6. Methodology and Scope

US Atopic Dermatitis Therapeutics Market Segmentation

By Drug Class

  • Corticosteroids
  • Calcineurin Inhibitors
  • Immunosuppressants
  • Biologic Therapy
  • PDE-4 Inhibitor
  • Antibiotics
  • Antihistamines
  • Emollients

By Route of Administration

  • Topic
  • Oral
  • Injectable

By Severity type

  • Mild
  • Moderate
  • Severe

By Age Group

  • 18 years and below
  • 19 years and above

By Distribution channel

  • Hospital Pharmacy
  • Retail Pharmacy
  • Online Pharmacy
  • Dermatology Clinics
  • Others

Insights10 will provide you with the reports within 10 key parameters which are:

  1. Market Overview
  2. Market Growth Drivers & Restraints
  3. Epidemiology of Disease Type
  4. Market Segmentation
  5. Market Share
  6. Competitive Landscape
  7. Key Company Profiles
  8. Healthcare Policies & Regulatory Framework
  9. Reimbursement Scenario
  10. Factors Driving Future Growth

Based on our many years of experience, we believe that these are the parameters that are critical to decision-making for business stakeholders. Our focused approach to developing reports focused on 10 key parameters, enabled us to arrive at the name “Insights10”.

 

Stage I: Market Data Collection

Primary Interviews: We have developed a network of experts, freelancers, and researchers across countries through which we engage with local experts to gather key data points and assumptions about each market. We also engage regularly with some of the best market research agencies such as Atheneum, GuidePoint, GLG, etc. to conduct surveys and interviews, and build intelligence. We have language translators as a part of our team, who between them can cover 30+ languages allowing us to extract better local insights.

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Data Sources: We have access to multiple highly reliable free and subscription data sources. We have many years of experience to understand which sources are more dependable for what and which to prefer for the reliable and latest information. The key sources of information include the following, but are not limited to:

 

 

Stage II: Market Data Analysis and Statistical Model

Market Trends: We generally look at macro parameters and micro indicators. The macro parameters include changes in government policies, demand and supply of the market, government intervention programs, and major market share. The micro indicators are GDP growth, market size, market volume, etc. We also understand nuances specific to each country like the US, Canada, India, Germany, etc., and have worked across 60+ countries and hence not only understand global trends but how these differ by country, how payment models, market structure, cultural parameters, etc. differ in each country.

Market Sizing and Analysis: Our expert data analytics team has created various market forecast models by employing the top-down approach i.e. starting with the large overall market and segmenting different areas and the bottom-up approach i.e. starting with population and epidemiology and rolling up based on spend, etc., estimating the size of the market, and distributing among the geographic and/or product segments.

The top-down approach is mainly used for new product forecasting and the bottom-up approach is used for demand estimation of any product for different countries summed up to form the total market. We are able to round off insights and build stronger forecasts because we always do both these methods and triangulate the final numbers.

The study on the market covers the analysis of the leading geographies such as Asia-Pacific, Africa, Europe, Middle East, North America, and  Latin America for the period of 2022 to 2030. The qualitative analysis covers the industry landscape and trends, market opportunities, competitive landscape, and policy and regulatory scenario, and the quantitative analysis covers different market estimates and forecasts.

Data Triangulation & Validation:

Data triangulation of various sources and results of the research are carried out by benchmarking with reliable sources such as industry statistics, statistical databases, and company-level averages, etc.

We make sure to finalize the numbers in alignment with the market research. Firstly, our internal experts ensure thorough validation and checking to ensure accurate and precise analysis and then validation is also done using a multiple-data analysis model. Two-level validation is done and entails the finalization of the report scope and the way of representation pattern.

 

 

Stage III: Interpretation and Presentation

Analysis & Interpretation: The information gathered is then analyzed and synthesized. The second series of interviews are done if necessary to check and validate. The future opportunities are analyzed by understanding product commercialization and many other factors. It also comprises the analysis of data discrepancies observed across various data sources. Information procured from secondary and primary results is then, interpreted by considering the following parameters: (a partial list)

  • Establishing market drivers and trends
  • Analyzing the regulatory landscape to understand future growth
  • Market Segment based analysis to obtain revenue/volume
  • ​Analyzing current needs and determining penetration to estimate the market

Insights: Our reports deliver actionable insights backed with supporting facts and figures to assist you in achieving exemplary growth. Our in-depth analyses are interspersed with relevant insights and statistics to offer an executive-level view of a given market. The description helps in correlating many minor factors affecting the market and their impact on the different segments within the market.

Data curated from the analysis and interpretation are drawn to portray all in one consolidated report.

Presentation & Reporting: The market research report is presented in different forms such as charts by using a scientific approach for easy understanding. Historic, current, and future analysis is provided for each market in terms of both value and volume. The size of the market is interpreted in the US Dollar value and the respective unit, based on the product, for volume consumption.

The foreign exchange rates are calculated on the respective dates and for the respective regions covered in the study.

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Last updated on: 11 March 2024
Updated by: Anish Swaminathan

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