US Huntington's Disease Therapeutics Market Analysis

US Huntington's Disease Therapeutics Market Analysis

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US huntington's disease therapeutics market is projected to grow from $xx Mn in 2023 to $xx Mn by 2030, registering a CAGR of xx% during the forecast period of 2023 ? 2030. The market for treating Huntington's disease is expanding due to a number of causes, including an increase in the disease's prevalence and a rise in the demand for modern drug types to treat the signs and symptoms of the disease. Some of the key players in the global Huntington's Disease Therapeutics Market include Pfizer, Inc. Alnylam Pharmaceuticals Inc. Teva Pharmaceutical Industries Ltd. Neurocrine Biosciences, Inc. Ionis Pharmaceuticals,Vertex Pharmaceuticals Incorporated (U.S.), Elekta AB (Sweden), Alterity Therapeutics (Australia) and som biotech (spain).


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US Huntington's Disease Therapeutics Market Analysis Summary

US Huntington's Disease Therapeutics Market is valued at around $0.36 Bn in 2022 and is projected to reach $14.93 Bn by 2030, exhibiting a CAGR of 59.5% during the forecast period 2023-2030.

In some parts of the brain, Huntington's disease (HD), an inherited condition, causes the progressive degeneration and death of nerve cells (neurons). Multiple parts of the brain are affected by the disease, including regions linked to the control of voluntary (intentional) movement.

One of the primary reasons influencing the market expansion for therapies for the condition is the onset of Huntington's disease symptoms, which increases the need for HD treatments. No of a person's cultural origins, HD affects both boys and females equally. An individual may suffer symptoms at any time in life due to the hereditary basis of the disorder. The person who inherits the disease-causing genes from their ill parents will probably become ill at some point in their lifespan.

The huge rise in the number of patients is one of the main market factors because it increases the demand for drugs and the biggest regional market for the treatment of Huntington's condition is North America.

The direct genetic test, which uses DNA extracted from a blood sample to quantify the number of CAG repeats in the HD gene, is the most accurate and trustworthy way to diagnose HD. Getting 36 or more repeats demonstrates the presence of HD. The aging global population and rising knowledge of Huntington's Disease and early detection are projected to fuel the market for therapeutics for the condition in the years to come. The market may yet have difficulties with regard to obtaining regulatory permission and funding for therapies, as well as the high price of various drugs and treatments involved in the same. Some of the key players in the global Huntington's Disease Therapeutics Market include Pfizer, Inc. Alnylam Pharmaceuticals Inc. Teva Pharmaceutical Industries Ltd. Neurocrine Biosciences, Inc. Ionis Pharmaceuticals, Vertex Pharmaceuticals Incorporated (U.S.), Elekta AB (Sweden), Alterity Therapeutics (Australia) and som biotech (Spain).

Market Dynamics

Market Drivers

The market for treating huntington's disease continues to expand due to a variety of causes, such as an increase in the incidence of the illness and a rise in the need for novel drug types to treat the disease's symptoms. Clinical studies and a robust drug pipeline are two other aspects of Huntington's disease treatment market that are anticipated to support the industry's expected rise.

Government initiatives to increase awareness of disease: Governmental organizations constantly roll out new initiatives, campaigns, and beneficiary programs all over the world to raise public awareness of this ailment and tell patients about their available treatment options. As a result of these efforts, which are predicted to raise the number of cases of the disease that are diagnosed, the demand for cutting-edge drugs is anticipated to rise. A code on genetic testing and insurance that the Association of British Insurers (ABI) and the U.K. government have signed states that if the predictive genetic test for this ailment is successful, the applicant will receive life insurance coverage for more than $694,444.4. The market will grow as a result of such government measures encouraging early detection and prompt treatment of patients with Huntington's disease.

Increasing Healthcare Expenditure: This market is expanding as a result of rising healthcare spending in both developed and developing nations. This demand is fueling the development of novel drug types to treat the disease's symptoms.

Growing Interest in Personalised Medicine: In the years to come, it is anticipated that the interest in individualized medicine will continue to fuel the development of Clinical studies and a robust drug pipeline for Huntington's disease treatment.

Market Restraints

Strict regulatory hurdles and a lack of licensed drugs may prevent the market from growing. Effectively two drugs that only treat or manage the disease's symptoms rather than its actual reason have received approval for chorea treatment. If chorea, one of a patient's primary and earliest physical symptoms, is neglected, it gets worse with time. Companies must submit to strict regulations from all around the world in order to obtain a license for their products.

For instance, clinical trials were initiated by Ionis Pharmaceuticals and F. Hoffmann-La Roche Ltd. to assess the effectiveness of tominersen in patients who developed this illness as younger adults. Tominersen, often referred to as IONIS-HTTRx and RG6042, is a research-stage antisense medication with the goal of reducing the production of the Huntington (HTT) protein. In March 2021, both companies stopped overseeing the Phase II GENERATION HD1 trial, against the Independent Data Monitoring Committee's (iDMC) recommendation that it be ended. The tight regulations prevented many pipeline prospects from demonstrating their efficacy, and many companies decided not to proceed with the pharmaceutical development process.

Even though the healthcare system was concentrating on the COVID-19 epidemic, these patients still need comprehensive care because Huntington's disease is a degenerative illness. It was further demonstrated that home treatment was preferred to inpatient rehabilitation. Therefore, it is anticipated that the COVID-19 epidemic will negatively affect the expansion of the world market for treating Huntington's disease.

Key players

Roche Holding AG Sanofi AbbVie Biogen Eli Lilly and Company Janssen Pharmaceuticals Novartis AG Pfizer Inc. Takeda Pharmaceutical Company UCB Pharma

1. Executive Summary
1.1 Disease Overview
1.2 Global Scenario
1.3 Country Overview
1.4 Healthcare Scenario in Country
1.5 Patient Journey
1.6 Health Insurance Coverage in Country
1.7 Active Pharmaceutical Ingredient (API)
1.8 Recent Developments in the Country

2. Market Size and Forecasting
2.1 Epidemiology of Disease
2.2 Market Size (With Excel & Methodology)
2.3 Market Segmentation (Check all Segments in Segmentation Section)

3. Market Dynamics
3.1 Market Drivers
3.2 Market Restraints

4. Competitive Landscape
4.1 Major Market Share

4.2 Key Company Profile (Check all Companies in the Summary Section)

4.2.1 Company Overview Product Applications and Services Recent Developments Partnerships Ecosystem Financials (Based on Availability)

5. Reimbursement Scenario
5.1 Reimbursement Regulation
5.2 Reimbursement Process for Diagnosis
5.3 Reimbursement Process for Treatment

6. Methodology and Scope

US Huntington's Disease Therapeutics Market Segmentation

By Treatment:

  • Symptomatic Treatment
  • Disease-Modifying Treatment

By Distribution Channel:

  • Hospital Pharmacies
  • Retail Pharmacies
  • Online Pharmacies

Insights10 will provide you with the reports within 10 key parameters which are:

  1. Market Overview
  2. Market Growth Drivers & Restraints
  3. Epidemiology of Disease Type
  4. Market Segmentation
  5. Market Share
  6. Competitive Landscape
  7. Key Company Profiles
  8. Healthcare Policies & Regulatory Framework
  9. Reimbursement Scenario
  10. Factors Driving Future Growth

Based on our many years of experience, we believe that these are the parameters that are critical to decision-making for business stakeholders. Our focused approach to developing reports focused on 10 key parameters, enabled us to arrive at the name “Insights10”.


Stage I: Market Data Collection

Primary Interviews: We have developed a network of experts, freelancers, and researchers across countries through which we engage with local experts to gather key data points and assumptions about each market. We also engage regularly with some of the best market research agencies such as Atheneum, GuidePoint, GLG, etc. to conduct surveys and interviews, and build intelligence. We have language translators as a part of our team, who between them can cover 30+ languages allowing us to extract better local insights.

Secondary Data Collection: We have developed strong expertise and experience in secondary data collection methods for developing unique data sets and research material. We gather data from multiple reliable sources to maintain a high level of accuracy and consistency. The market data is analyzed and forecasted using appropriate statistical and coherent models. The report offers an overall analysis of the market size, growth, and market share as well as a segment-level analysis of the specific market. Our report includes precise, to-the-point information related to the overall market, competition, growth drivers, challenges, regulatory updates, and competition.

Data Sources: We have access to multiple highly reliable free and subscription data sources. We have many years of experience to understand which sources are more dependable for what and which to prefer for the reliable and latest information. The key sources of information include the following, but are not limited to:



Stage II: Market Data Analysis and Statistical Model

Market Trends: We generally look at macro parameters and micro indicators. The macro parameters include changes in government policies, demand and supply of the market, government intervention programs, and major market share. The micro indicators are GDP growth, market size, market volume, etc. We also understand nuances specific to each country like the US, Canada, India, Germany, etc., and have worked across 60+ countries and hence not only understand global trends but how these differ by country, how payment models, market structure, cultural parameters, etc. differ in each country.

Market Sizing and Analysis: Our expert data analytics team has created various market forecast models by employing the top-down approach i.e. starting with the large overall market and segmenting different areas and the bottom-up approach i.e. starting with population and epidemiology and rolling up based on spend, etc., estimating the size of the market, and distributing among the geographic and/or product segments.

The top-down approach is mainly used for new product forecasting and the bottom-up approach is used for demand estimation of any product for different countries summed up to form the total market. We are able to round off insights and build stronger forecasts because we always do both these methods and triangulate the final numbers.

The study on the market covers the analysis of the leading geographies such as Asia-Pacific, Africa, Europe, Middle East, North America, and  Latin America for the period of 2022 to 2030. The qualitative analysis covers the industry landscape and trends, market opportunities, competitive landscape, and policy and regulatory scenario, and the quantitative analysis covers different market estimates and forecasts.

Data Triangulation & Validation:

Data triangulation of various sources and results of the research are carried out by benchmarking with reliable sources such as industry statistics, statistical databases, and company-level averages, etc.

We make sure to finalize the numbers in alignment with the market research. Firstly, our internal experts ensure thorough validation and checking to ensure accurate and precise analysis and then validation is also done using a multiple-data analysis model. Two-level validation is done and entails the finalization of the report scope and the way of representation pattern.



Stage III: Interpretation and Presentation

Analysis & Interpretation: The information gathered is then analyzed and synthesized. The second series of interviews are done if necessary to check and validate. The future opportunities are analyzed by understanding product commercialization and many other factors. It also comprises the analysis of data discrepancies observed across various data sources. Information procured from secondary and primary results is then, interpreted by considering the following parameters: (a partial list)

  • Establishing market drivers and trends
  • Analyzing the regulatory landscape to understand future growth
  • Market Segment based analysis to obtain revenue/volume
  • ​Analyzing current needs and determining penetration to estimate the market

Insights: Our reports deliver actionable insights backed with supporting facts and figures to assist you in achieving exemplary growth. Our in-depth analyses are interspersed with relevant insights and statistics to offer an executive-level view of a given market. The description helps in correlating many minor factors affecting the market and their impact on the different segments within the market.

Data curated from the analysis and interpretation are drawn to portray all in one consolidated report.

Presentation & Reporting: The market research report is presented in different forms such as charts by using a scientific approach for easy understanding. Historic, current, and future analysis is provided for each market in terms of both value and volume. The size of the market is interpreted in the US Dollar value and the respective unit, based on the product, for volume consumption.

The foreign exchange rates are calculated on the respective dates and for the respective regions covered in the study.

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This report addresses

  • Intelligent insights to take informed business decisions
  • Qualitative, acute and result oriented market analysis
  • Market size and forecasts from 2022 to 2030
  • Opportunities for expansion and in-depth market analysis
  • Segmentation and regional revenue forecasts
  • Analysis of the market share and competitive landscape
  • Strategic Recommendations to chart future course of action
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Last updated on: 04 July 2023
Updated by: Keta Vora

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