Japan Alzheimer’s Therapeutics Market Analysis

Japan Alzheimer’s Therapeutics Market Analysis


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Japan alzheimer’s therapeutics market valued at $298 Mn in 2022, projected to reach $621 Mn by 2030 with a 9.6% CAGR. The growing prevalence of Alzheimer's disease, which is fuelled by an aging population, is one major factor driving the market for drugs used to treat the condition. The leading pharmaceutical companies currently operating in the market are Eisai, Otsuka Holdings Co., Astellas Pharma Inc., Mitsubishi Tanabe Pharma Corporation, Sumitomo Dainippon Pharma Co., Takeda Pharmaceutical Company, Roche Holding, Novartis, Pfizer, and Lundbec.

ID: IN10JPPH431 CATEGORY: Pharmaceuticals GEOGRAPHY: Japan AUTHOR: Dr. Medha Sansanwal

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Japan Alzheimer’s Therapeutics Market Executive Summary

Japan alzheimer’s therapeutics market valued at $298 Mn in 2022, projected to reach $621 Mn by 2030 with a 9.6% CAGR.

Alzheimer's disease is a neurological disorder that affects memory, behavior, and mental health. Usually, it begins gradually, worsens over time, and makes it more difficult for the affected individual to do everyday duties. In Alzheimer's disease, aberrant brain changes such as plaque and tangle formation cause nerve cells to die. There is presently no treatment for Alzheimer's disease. On the other hand, some medications can improve quality of life and aid with symptom management. These drugs alter certain neurotransmitters in the brain to treat memory and cognitive problems. Donepezil, rivastigmine, and memantine are a few of these drugs. Maintaining a healthy lifestyle, participating in social and cognitive activities, and creating a supportive environment are examples of non-pharmacological strategies that may enhance overall illness management.

Over 4.6 Mn people in Japan suffer from dementia, accounting for about 7% of those 65 and older. Alzheimer's disease (AD) is the most common type of dementia. Forecasts suggest a worrying increase: by 2025, there will be more than 5.3 Mn dementia sufferers worldwide, and by 2060, that figure will jump to 8.1 Mn. Age is a key factor in prevalence; 10% of people 75 years of age and beyond are thought to have dementia. Regional differences are also apparent, with incidence rates higher in rural than in urban settings, which can be linked to things like restricted access to diagnostic resources and healthcare. The growing prevalence of Alzheimer's disease presents serious obstacles for families, social care providers, and healthcare systems. Underscoring the need for prompt detection and intervention, current research initiatives in Japan and around the world seek to create novel diagnostic techniques, efficacious therapies, and, in the end, a cure for Alzheimer's disease.

LDP-002/GS-9657, a promising Alzheimer's treatment candidate from Otsuka, is presently completing Phase III clinical trials. Results are expected later this year, and the drug is intended to target Tau protein aggregation.

Aiming to lower amyloid-beta and Tau aggregation, Eisai and Sumitomo Dainippon Pharma are now conducting Phase II trials for their respective experimental medications. Apart from this, a multitude of other pharmaceutical businesses operating in Japan are leading the way in the advancement of early-stage clinical trials for possible Alzheimer's medications. Together, these companies add to the ever-changing field of Alzheimer's disease research and treatment development in Japan.

Japan alzheimer's therapeutics market

Market Dynamics

Market Growth Drivers

Rising Aging Population: With more than 28% of its population over 65, Japan has the oldest population in the world. Given that the prevalence of Alzheimer's increases with age, this demographic shift immediately translates into an increased risk of the illness.

Growing Awareness and Diagnosis: The stigma associated with Alzheimer's disease is progressively fading, resulting in heightened consciousness and prompt diagnosis. This trend is further supported by easier access to medical facilities and diagnostic technologies like brain scans.

Unaddressed Medical Demand and Changing Treatment Scenario: Alzheimer's disease does not currently have a recognized cure; current treatments only deal with the symptoms. The market for the creation of new, possibly more effective medications is substantial because there are few readily available medical treatments. Better tau-targeting drug development and therapy combinations, together with recent developments with anti-amyloid antibodies like lecanemab, all portend well for more potent treatments in the years to come.

Market Restraints

High Costs: Pharmaceuticals such as Leqembi can cost more than $0.02 million annually, which puts a heavy financial strain on patients and their families. This presents issues with pricing and accessibility, which may restrict drug use and market expansion. The affordability problem is made worse by limited insurance coverage for chronic illnesses like Alzheimer's, which forces patients to pay a large portion of their treatment out of the source.

Limited Access to Specialists: The majority of neurologists and other experts in the treatment of Alzheimer's disease reside in cities. Due to this, rural communities have less access to appropriate diagnosis, care, and follow-up, which hinders patient benefits and market penetration.

Lack of Awareness and Stigma: Despite the increasing number of awareness initiatives, many people are unable to receive a diagnosis and treatment for dementia and Alzheimer's disease due to the ongoing cultural stigma around these conditions. This stigma is one of the primary obstacles keeping the market from reaching a wider range of consumers.

Healthcare Policies and Regulatory Landscape

The Ministry of Health, Labour, and Welfare (MHLW) and the Pharmaceuticals and Medical Devices Agency (PMDA) in Japan collaborate to manage therapeutic drug regulations and healthcare policy. As the main regulatory agency, the PMDA carefully assesses and approves medications by going over clinical trial data, production procedures, and quality control protocols in detail. The PMDA works closely with peers abroad to standardize regulatory requirements. In addition to developing healthcare policy, the MHLW also assists in the development of drug pricing and reimbursement plans, which are supervised by the Central Social Insurance Medical Council (Chuikyo). Preclinical and clinical data are scrutinized closely during the clearance process, and post-marketing surveillance guarantees ongoing safety oversight.

Competitive Landscape

Key Players

  • Eisai
  • Otsuka Holdings Co.
  • Astellas Pharma Inc.
  • Mitsubishi Tanabe Pharma Corporation
  • Sumitomo Dainippon Pharma Co.
  • Takeda Pharmaceutical Company
  • Roche Holding
  • Novartis
  • Pfizer
  • Lundbec.

1. Executive Summary
1.1 Disease Overview
1.2 Global Scenario
1.3 Country Overview
1.4 Healthcare Scenario in Country
1.5 Patient Journey
1.6 Health Insurance Coverage in Country
1.7 Active Pharmaceutical Ingredient (API)
1.8 Recent Developments in the Country

2. Market Size and Forecasting
2.1 Epidemiology of Disease
2.2 Market Size (With Excel & Methodology)
2.3 Market Segmentation (Check all Segments in Segmentation Section)

3. Market Dynamics
3.1 Market Drivers
3.2 Market Restraints

4. Competitive Landscape
4.1 Major Market Share

4.2 Key Company Profile (Check all Companies in the Summary Section)

4.2.1 Company
4.2.1.1 Overview
4.2.1.2 Product Applications and Services
4.2.1.3 Recent Developments
4.2.1.4 Partnerships Ecosystem
4.2.1.5 Financials (Based on Availability)

5. Reimbursement Scenario
5.1 Reimbursement Regulation
5.2 Reimbursement Process for Diagnosis
5.3 Reimbursement Process for Treatment

6. Methodology and Scope

Japan Alzheimer’s Therapeutics Market Segmentation

By Drug Name

  • Early-Onset Alzheimer's
  • Late-Onset Alzheimer's
  • Familial Alzheimer's disease

By Drug Name

  • Donepezil
  • Rivastigmine
  • Memantine
  • Galantamine
  • Manufactured a combination of memantine and donepezil

By Drug Class

  • Cholinesterase Inhibitors
  • NMDA Receptor Antagonists
  • Manufactured Combination

By End-Users

  • Hospitals
  • Specialty Clinics
  • Homecare
  • Others

By Distribution Channel

  • Hospital pharmacies
  • Drug stores
  • Retail pharmacies
  • Online pharmacies
  • Other distribution channel

Insights10 will provide you with the reports within 10 key parameters which are:

  1. Market Overview
  2. Market Growth Drivers & Restraints
  3. Epidemiology of Disease Type
  4. Market Segmentation
  5. Market Share
  6. Competitive Landscape
  7. Key Company Profiles
  8. Healthcare Policies & Regulatory Framework
  9. Reimbursement Scenario
  10. Factors Driving Future Growth

Based on our many years of experience, we believe that these are the parameters that are critical to decision-making for business stakeholders. Our focused approach to developing reports focused on 10 key parameters, enabled us to arrive at the name “Insights10”.

 

Stage I: Market Data Collection

Primary Interviews: We have developed a network of experts, freelancers, and researchers across countries through which we engage with local experts to gather key data points and assumptions about each market. We also engage regularly with some of the best market research agencies such as Atheneum, GuidePoint, GLG, etc. to conduct surveys and interviews, and build intelligence. We have language translators as a part of our team, who between them can cover 30+ languages allowing us to extract better local insights.

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Data Sources: We have access to multiple highly reliable free and subscription data sources. We have many years of experience to understand which sources are more dependable for what and which to prefer for the reliable and latest information. The key sources of information include the following, but are not limited to:

 

 

Stage II: Market Data Analysis and Statistical Model

Market Trends: We generally look at macro parameters and micro indicators. The macro parameters include changes in government policies, demand and supply of the market, government intervention programs, and major market share. The micro indicators are GDP growth, market size, market volume, etc. We also understand nuances specific to each country like the US, Canada, India, Germany, etc., and have worked across 60+ countries and hence not only understand global trends but how these differ by country, how payment models, market structure, cultural parameters, etc. differ in each country.

Market Sizing and Analysis: Our expert data analytics team has created various market forecast models by employing the top-down approach i.e. starting with the large overall market and segmenting different areas and the bottom-up approach i.e. starting with population and epidemiology and rolling up based on spend, etc., estimating the size of the market, and distributing among the geographic and/or product segments.

The top-down approach is mainly used for new product forecasting and the bottom-up approach is used for demand estimation of any product for different countries summed up to form the total market. We are able to round off insights and build stronger forecasts because we always do both these methods and triangulate the final numbers.

The study on the market covers the analysis of the leading geographies such as Asia-Pacific, Africa, Europe, Middle East, North America, and  Latin America for the period of 2022 to 2030. The qualitative analysis covers the industry landscape and trends, market opportunities, competitive landscape, and policy and regulatory scenario, and the quantitative analysis covers different market estimates and forecasts.

Data Triangulation & Validation:

Data triangulation of various sources and results of the research are carried out by benchmarking with reliable sources such as industry statistics, statistical databases, and company-level averages, etc.

We make sure to finalize the numbers in alignment with the market research. Firstly, our internal experts ensure thorough validation and checking to ensure accurate and precise analysis and then validation is also done using a multiple-data analysis model. Two-level validation is done and entails the finalization of the report scope and the way of representation pattern.

 

 

Stage III: Interpretation and Presentation

Analysis & Interpretation: The information gathered is then analyzed and synthesized. The second series of interviews are done if necessary to check and validate. The future opportunities are analyzed by understanding product commercialization and many other factors. It also comprises the analysis of data discrepancies observed across various data sources. Information procured from secondary and primary results is then, interpreted by considering the following parameters: (a partial list)

  • Establishing market drivers and trends
  • Analyzing the regulatory landscape to understand future growth
  • Market Segment based analysis to obtain revenue/volume
  • ​Analyzing current needs and determining penetration to estimate the market

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Data curated from the analysis and interpretation are drawn to portray all in one consolidated report.

Presentation & Reporting: The market research report is presented in different forms such as charts by using a scientific approach for easy understanding. Historic, current, and future analysis is provided for each market in terms of both value and volume. The size of the market is interpreted in the US Dollar value and the respective unit, based on the product, for volume consumption.

The foreign exchange rates are calculated on the respective dates and for the respective regions covered in the study.

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Last updated on: 09 April 2024
Updated by: Anish Swaminathan

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