India Multiple Myeloma Therapeutics Market Analysis

India Multiple Myeloma Therapeutics Market Analysis


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India's multiple myeloma therapeutics market was valued at $152 Mn in 2022 and is estimated to expand at a CAGR of 7.5% from 2022 to 2030 and will reach $271 Mn in 2030. One of the main reasons propelling the growth of this market is the increase in prevalence, Increasing awareness, and screening programs. The Market is segmented by type, drug, and distribution channel. Some key players in this market are Natco Pharma, Cipla, Hetero Drugs, Biocon, Dr. Reddy's Laboratories, Sun Pharmaceutical Industries, Lupin, Cadila Healthcare, and others.

ID: IN10INPH301 CATEGORY: Rare Diseases GEOGRAPHY: India AUTHOR: Nandini Shah

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India Multiple Myeloma Therapeutics Market Executive Summary

The India Multiple Myeloma Therapeutics Market was valued at $152 Mn in 2022 and is estimated to expand at a CAGR of 7.5% from 2022 to 2030 and will reach $271 Mn in 2030. Multiple myeloma is a kind of malignancy that affects bone marrow plasma cells. Multiple myeloma is one of the most rapidly spreading cancers in India, and its frequency is rising significantly. According to research by the Indian Council of Medical Research, the incidence of multiple myeloma in India is approximately 2 to 3 per 100,000 people, with the disease being more prevalent in the country's southern and western areas. In the future years, the Indian market for multiple myeloma therapies is anticipated to experience considerable expansion due to factors such as the disease's rising prevalence, rising awareness and screening programs, and the availability of sophisticated treatments.

india multiple myeloma therapeutics market

Market Dynamics

Market Growth Drivers

The incidence of multiple myeloma in India is on the rise, which is a major growth driver for the market. According to the Indian Journal of Medical and Paediatric Oncology, the incidence of multiple myeloma in India is increasing at a rate of 10-15% annually. The aging population in India is increasing, which is also contributing to the growth of the multiple myeloma therapeutics market. As people age, the risk of developing multiple myeloma increases. The Indian government is increasing its healthcare spending, which is expected to boost the market for multiple myeloma therapeutics.

The government has launched several initiatives to improve healthcare access and affordability for the population, which is likely to increase the demand for multiple myeloma therapeutics. The development of new technologies and treatment methods is driving the growth of the multiple myeloma therapeutics market in India. The use of targeted therapies, immunomodulatory drugs, and stem cell transplantations has improved the survival rate and quality of life of patients with multiple myeloma. The awareness about multiple myeloma and screening programs has increased in India, which is expected to drive the growth of the market. The Indian government has launched several initiatives to raise awareness about multiple myeloma, which is expected to increase the demand for therapeutics.

Market Restraints

A significant challenge in India is limited access to healthcare, particularly in rural areas, which can result in delays in the diagnosis and treatment of multiple myeloma. Multiple myeloma is a relatively rare disease, and many patients may not be aware of the condition and its symptoms, resulting in a delayed diagnosis and poor outcomes. The cost of treatment for multiple myeloma can be high, making it difficult for many patients to access the necessary care. The availability of multiple myeloma medications in India is limited, which can result in delays in treatment and limited treatment options. The infrastructure for diagnosing and treating multiple myeloma in India can be inadequate, particularly in rural areas, which can limit access to care and result in poor outcomes. There is a shortage of healthcare professionals in India, including oncologists, which can limit access to care and result in delays in diagnosis and treatment. The regulatory environment in India can be challenging for pharmaceutical companies, which can result in delays in drug approvals and limited access to innovative therapies.

Competitive Landscape

Key Players

  • Natco Pharma
  • Cipla
  • Hetero Drugs
  • Biocon
  • Dr. Reddy's Laboratories
  • Sun Pharmaceutical Industries
  • Lupin
  • Cadila Healthcare
  • Alembic Pharmaceuticals
  • Emcure Pharmaceuticals

Healthcare Policies and Regulatory Landscape

In India, the healthcare policy and regulatory landscape is overseen by several bodies, including the Ministry of Health and Family Welfare (MOHFW), the Central Drugs Standard Control Organization (CDSCO), and the National Pharmaceuticals Pricing Authority (NPPA). The MOHFW is responsible for the formulation of policies, the implementation of programs, and the regulation of healthcare services. The CDSCO is responsible for the regulation of drugs and medical devices, including the approval and licensing of new drugs. The NPPA is responsible for controlling the prices of drugs and ensuring their availability.

The Indian government has implemented several policies aimed at promoting healthcare in the country, including the Ayushman Bharat scheme, which aims to provide free healthcare to over 100 Mn families. The government has also launched the National Health Stack, which is a collection of digital health services aimed at making healthcare more accessible and affordable for all Indians.

In terms of the regulatory landscape, India follows a drug approval process that is similar to that of the US FDA. The CDSCO has established guidelines for the conduct of clinical trials in the country. These guidelines require that all clinical trials be conducted in accordance with the International Conference on Harmonization-Good Clinical Practice (ICH-GCP) guidelines. The CDSCO also requires that all drugs undergo clinical trials in India before they can be approved for marketing.

Reimbursement Scenario

In India, the reimbursement scenario for multiple myeloma therapeutics is largely dependent on the type of health insurance coverage that patients have. The public health insurance system, known as the Pradhan Mantri Jan Arogya Yojana (PMJAY) or Ayushman Bharat, provides free treatment to eligible patients for a select number of diseases, including cancer. However, the coverage is limited, and patients may not receive the full range of treatments available.

Private health insurance plans are also available in India, but their coverage and reimbursement policies can vary widely depending on the plan and the provider. Some plans may cover a limited range of treatments, while others may cover more comprehensive treatment options.

1. Executive Summary
1.1 Disease Overview
1.2 Global Scenario
1.3 Country Overview
1.4 Healthcare Scenario in Country
1.5 Patient Journey
1.6 Health Insurance Coverage in Country
1.7 Active Pharmaceutical Ingredient (API)
1.8 Recent Developments in the Country

2. Market Size and Forecasting
2.1 Epidemiology of Disease
2.2 Market Size (With Excel & Methodology)
2.3 Market Segmentation (Check all Segments in Segmentation Section)

3. Market Dynamics
3.1 Market Drivers
3.2 Market Restraints

4. Competitive Landscape
4.1 Major Market Share

4.2 Key Company Profile (Check all Companies in the Summary Section)

4.2.1 Company
4.2.1.1 Overview
4.2.1.2 Product Applications and Services
4.2.1.3 Recent Developments
4.2.1.4 Partnerships Ecosystem
4.2.1.5 Financials (Based on Availability)

5. Reimbursement Scenario
5.1 Reimbursement Regulation
5.2 Reimbursement Process for Diagnosis
5.3 Reimbursement Process for Treatment

6. Methodology and Scope

India Multiple Myeloma Therapeutics Market Segmentation

By Treatment

  • Chemotherapy
  • Immunotherapy
  • Targeted therapy
  • Radiation therapy
  • Stem cell transplant

By Distribution Channel

  • Hospitals
  • Retail
  • Online

By End User (Revenue, USD Bn):

  • Hospitals
  • Clinics
  • Cancer Research Centers

By Drug Class

Immunomodulatory Drugs (IMiDs)

One of the most common therapies used to treat myeloma is immunomodulatory drugs or IMiDs. These drugs work by modifying the immune system to attack myeloma cells and have been a significant advance in the treatment of multiple myeloma. Some of the commonly used IMiDs in multiple myeloma include:

  • Lenalidomide (Revlimid): Lenalidomide is an oral medication that is used in the treatment of multiple myeloma, as well as other blood cancers such as myelodysplastic syndromes (MDS). It may help the immune system in eliminating cancerous or abnormal blood cells. Moreover, it might stop the development of new blood vessels that tumors require to expand
  • Pomalidomide (Pomalyst): Pomalidomide is an oral medication that is used to treat multiple myeloma. It works in a similar way to lenalidomide, by enhancing the immune system's ability to target cancer cells. Also, it makes it easier for immune cells to eliminate faulty myeloma cells, aiding in the production of healthy blood cells in the myeloma
  • Thalidomide (Thalomid): Thalidomide was the first IMiD to be used in the treatment of multiple myeloma. It works by modulating the immune system and preventing the growth of blood vessels that supply the tumor
  • CC- 4047 (Actimid): CC-4047 is a newer IMiD that is still under investigation for the treatment of multiple myeloma. It works by inhibiting the growth of cancer cells and promoting their death

Proteasome Inhibitors

Proteasome inhibitors are a class of drugs that are commonly used in the treatment of multiple myeloma. They work by blocking the activity of proteasomes, which are cellular structures that break down proteins. This leads to the accumulation of proteins within the myeloma cells, ultimately causing their death. Some proteasome inhibitors used in multiple myeloma include:

  • Bortezomib (Velcade): Bortezomib was the first proteasome inhibitor approved for the treatment of multiple myeloma. It is given by injection and is often used in combination with other drugs, such as chemotherapy or immunomodulatory drugs. Bortezomib is highly effective in inducing remissions in newly diagnosed and relapsed/refractory multiple myeloma patients
  • Carfilzomib (Kyprolis): Carfilzomib is a newer proteasome inhibitor that is approved for the treatment of multiple myeloma. It is given by injection and can be used as a single agent or in combination with other drugs. Carfilzomib has shown excellent results in heavily pretreated patients with relapsed/refractory multiple myeloma
  • Ixazomib (Ninlaro): Ixazomib is an oral proteasome inhibitor that is approved for use in combination with lenalidomide and dexamethasone for the treatment of multiple myeloma. It is the first oral proteasome inhibitor and offers the convenience of home administration

Monoclonal Antibodies:

Monoclonal antibodies, target specific proteins on the surface of myeloma cells, causing them to be destroyed by the immune system. Some of the commonly used monoclonal antibodies in multiple myeloma include:

  • Daratumumab (Darzalex): Daratumumab is a monoclonal antibody that targets a protein called CD38, which is highly expressed on the surface of myeloma cells. By binding to CD38, daratumumab triggers the immune system to attack and destroy cancer cells. It is approved for use in multiple myeloma in combination with other drugs, such as lenalidomide or bortezomib.
  • Elotuzumab (Empliciti): Elotuzumab is a monoclonal antibody that targets a protein called SLAMF7, which is also expressed on the surface of myeloma cells. By binding to SLAMF7, elotuzumab enhances the immune system's ability to attack cancer cells. It is approved for use in combination with lenalidomide and dexamethasone for the treatment of multiple myeloma.
  • Isatuximab (Sarclisa): Isatuximab is a monoclonal antibody that targets a protein called CD38, similar to daratumumab. By binding to CD38, isatuximab triggers the immune system to attack and destroy cancer cells. It is approved for use in combination with pomalidomide and dexamethasone for the treatment of multiple myeloma.

Chemotherapy Drugs

Chemotherapy drugs work by killing rapidly dividing cells, including cancer cells. Chemotherapy is often used in combination with other drugs, such as steroids, immunomodulatory drugs, or proteasome inhibitors, to improve their effectiveness. Here are some chemotherapy drugs used in multiple myeloma:

  • Melphalan: Melphalan is an alkylating agent that is commonly used in the treatment of multiple myeloma. It is used as a preventative measure before having a stem cell transplant to treat multiple myeloma. It works by damaging the DNA of cancer cells, leading to their death. Melphalan is often used in combination with other drugs, such as prednisone, to treat newly diagnosed multiple myeloma.
  • Cyclophosphamide: Cyclophosphamide works by damaging the DNA of cancer cells, leading to their death. Cyclophosphamide is often used in combination with other drugs, such as dexamethasone, to treat relapsed or refractory multiple myeloma. Cyclophosphamide inhibits cancer cell proliferation, causing the body to kill the cancer cells.
  • Doxorubicin: Doxorubicin works by inhibiting the synthesis of DNA and RNA, leading to the death of cancer cells. Doxorubicin is often used in combination with other drugs, such as bortezomib or dexamethasone, to treat newly diagnosed or relapsed/refractory multiple myeloma. Doxorubicin belongs to the anthracycline class of chemotherapeutic drugs, which also includes daunorubicin, idarubicin, and epirubicin.
  • Etoposide: Etoposide is a topoisomerase inhibitor chemotherapy drug that is used in the treatment of multiple myeloma. It works by inhibiting the activity of topoisomerase enzymes, which are necessary for DNA replication and repair. Etoposide is often used in combination with other drugs, such as cisplatin, to treat relapsed or refractory multiple myeloma. It works by reducing or preventing cancer cell proliferation in your body.

Steroids

Steroids such as dexamethasone and prednisone are often used in combination with other drugs to treat multiple myeloma. They can reduce inflammation, suppress the immune system, and promote the death of myeloma cells.

  • Dexamethasone: Dexamethasone works by reducing inflammation and suppressing the immune system. Dexamethasone is often used in combination with other drugs to treat relapsed or refractory multiple myeloma.
  • Prednisone: Prednisone works by suppressing the immune system and reducing inflammation. Prednisone is often used in combination with other drugs, such as chemotherapy, to treat newly diagnosed multiple myeloma.
  • Methylprednisolone: Methylprednisolone is a steroid that is similar to prednisone and is also used in the treatment of multiple myeloma. It works by suppressing the immune system and reducing inflammation. Methylprednisolone is often used in combination with other drugs to treat relapsed or refractory multiple myeloma.

Steroids are effective in reducing inflammation and suppressing the immune system, which can help to control the growth of myeloma cells. However, they can have side effects, such as weight gain, mood changes, and increased risk of infection, so their use needs to be carefully monitored.

Others

Other drug classes used to treat multiple myeloma include:

  • Histone deacetylase inhibitors- A new class of cytostatic drugs that suppress tumor cell proliferation in vitro and in vivo by inducing cell cycle arrest, differentiation, and/or apoptosis
  • Immune checkpoint inhibitors- Checkpoint proteins are produced by some immune system cells, such as T cells, as well as some cancer cells. These checkpoints prevent too-aggressive immune responses and, in some cases, prevent T cells from destroying cancer cells
  • Targeted & therapies- Proteasome inhibitors are one type of targeted therapy for multiple myeloma. Proteasome inhibitors include bortezomib (Velcade), carfilzomib (Kyprolis), and ixazomib (Ninlaro). They target proteasomes, which are enzymes that break down proteins in cells

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  2. Market Growth Drivers & Restraints
  3. Epidemiology of Disease Type
  4. Market Segmentation
  5. Market Share
  6. Competitive Landscape
  7. Key Company Profiles
  8. Healthcare Policies & Regulatory Framework
  9. Reimbursement Scenario
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Last updated on: 27 September 2023
Updated by: Ritu Baliya

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