France Multiple Myeloma Therapeutics Market Analysis

France Multiple Myeloma Therapeutics Market Analysis


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The France Multiple Myeloma Therapeutics Market was valued at $229 Mn in 2022 and is estimated to expand at a CAGR of 3.5% from 2022 to 2030 and will reach $302 Mn in 2030. In One of the main reasons propelling the growth of this Market is Government initiatives and funding, aging population. The Market is segmented by type, drug and distribution channel. Some key players in this Market are Onxeo, Nanobiotix, AB Science, Servier, Sigma Aldrich and others.

ID: IN10FRPH301 CATEGORY: Rare Diseases GEOGRAPHY: France AUTHOR: Nandini Shah

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France Multiple Myeloma Therapeutics Market Executive Summary

The France Multiple Myeloma Therapeutics Market was valued at $229 Mn in 2022 and is estimated to expand at a CAGR of 3.5% from 2022 to 2030 and will reach $302 Mn in 2030. In the majority of instances, multiple myeloma is defined by the clonal proliferation of plasma cells responsible for an invasion of the haematological bone marrow and the release of a monoclonal immunoglobulin. It accounts for 1 to 2 percent of all cancers and 10 to 12 percent of all haematological malignancies, with around 5,400 new cases each year in France. The median age upon diagnosis is close to 70, with one-third of patients being over the age of 75 and one-fifth being over the age of 80.

France Multiple Myeloma Therapeutics Market

Market Dynamics

Market Growth Drivers

According to the French National Cancer Institute, there were an estimated 5400 new cases of multiple myeloma diagnosed in France in 2022. This increasing incidence is expected to drive the growth of the multiple myeloma therapeutics market in France. The approval of new and innovative therapies, such as proteasome inhibitors and immunomodulatory drugs, has significantly improved the survival rates and outcomes for multiple myeloma patients in France. The availability of these therapies is expected to drive the growth of the market. The growing demand for personalized and precision medicine is expected to drive the growth of the multiple myeloma therapeutics market in France. Advances in molecular and genetic profiling have enabled the development of more targeted and effective therapies for multiple myeloma. The French government has implemented various initiatives and funding programs to support research and development in the field of multiple myeloma therapeutics. This support is expected to drive the growth of the market by encouraging the development of new and innovative therapies. The aging population in France is expected to drive the growth of the multiple myeloma therapeutics market, as the incidence of multiple myeloma increases with age.

Market Restraints

The high cost of multiple myeloma therapeutics is a major challenge for patients and healthcare systems in France. The cost of new and innovative therapies, such as proteasome inhibitors and immunomodulatory drugs, can be prohibitively expensive, limiting access for many patients. Patients with refractory multiple myeloma, who have failed to respond to multiple lines of therapy, have limited treatment options in France. This is a major challenge, as refractory disease is associated with poor outcomes and a reduced quality of life. Multiple myeloma therapeutics can cause a range of adverse effects, including fatigue, neuropathy, and hematologic toxicities. These adverse effects can have a significant impact on patients' quality of life and may limit the use of certain therapies. Delays in the diagnosis and treatment of multiple myeloma can have a significant impact on patient outcomes. In France, delays in diagnosis and treatment can occur due to a range of factors, including limited access to specialized healthcare services and diagnostic testing. Clinical trials are an important tool for advancing the development of new and innovative therapies for multiple myeloma. However, access to clinical trials can be limited in France, particularly for patients in remote or rural areas.

Competitive Landscape

Key Players

  • Cellectis
  • Onxeo
  • Nanobiotix
  • AB Science
  • Servier
  • Sigma Aldrich
  • Novartis
  • Sanofi

 Healthcare Policies and Regulatory Landscape

The French National Authority for Health (HAS): HAS is responsible for evaluating the clinical and economic effectiveness of medical products and technologies, including multiple myeloma therapeutics.

The French National Cancer Institute (INCa) is responsible for coordinating and implementing cancer control policies in France, including the development of guidelines for the diagnosis and treatment of multiple myeloma.

The French Health Products Safety Agency (ANSM) is responsible for regulating the safety and efficacy of medical products, including multiple myeloma therapeutics.

The Ministry of Health is responsible for setting healthcare policies and overseeing the implementation of healthcare services and programs, including those related to multiple myeloma. While the Social Security System provides healthcare coverage to all residents of France, including coverage for multiple myeloma treatment.

The regulatory framework for multiple myeloma therapeutics in France is generally considered to be rigorous, with a focus on ensuring the safety and efficacy of new and innovative therapies. However, some stakeholders have raised concerns about the length and complexity of the regulatory process, which can delay patient access to new treatments. Efforts are underway to streamline the regulatory process and reduce barriers to patient access to innovative therapies.

Reimbursement Scenario

In France, the reimbursement of multiple myeloma treatments is primarily covered by the national healthcare system, which is financed through a combination of government funding and mandatory contributions from employers and employees. The reimbursement system is overseen by the National Health Insurance Fund (CNAM), which sets the reimbursement rates for medical services and treatments.

The reimbursement rates for multiple myeloma treatments in France are generally considered to be high, with a high percentage of the cost of treatment covered by the national healthcare system. However, there are some limitations on coverage for certain treatments, and some patients may experience out-of-pocket costs associated with their treatment.

To be eligible for reimbursement, multiple myeloma treatments must be approved by the French National Authority for Health (HAS) and be included on the list of reimbursable treatments. This list, known as the Liste des Produits et Prestations Remboursables (LPPR), is updated regularly and includes a range of medical products and services, including drugs, medical devices, and procedures.

In addition to the national healthcare system, some patients may also have access to supplemental private insurance, which can provide additional coverage for medical expenses not covered by the national healthcare system. However, access to private insurance is typically limited to those with higher incomes or those who are employed in certain industries. 

 

1. Executive Summary
1.1 Disease Overview
1.2 Global Scenario
1.3 Country Overview
1.4 Healthcare Scenario in Country
1.5 Patient Journey
1.6 Health Insurance Coverage in Country
1.7 Active Pharmaceutical Ingredient (API)
1.8 Recent Developments in the Country

2. Market Size and Forecasting
2.1 Epidemiology of Disease
2.2 Market Size (With Excel & Methodology)
2.3 Market Segmentation (Check all Segments in Segmentation Section)

3. Market Dynamics
3.1 Market Drivers
3.2 Market Restraints

4. Competitive Landscape
4.1 Major Market Share

4.2 Key Company Profile (Check all Companies in the Summary Section)

4.2.1 Company
4.2.1.1 Overview
4.2.1.2 Product Applications and Services
4.2.1.3 Recent Developments
4.2.1.4 Partnerships Ecosystem
4.2.1.5 Financials (Based on Availability)

5. Reimbursement Scenario
5.1 Reimbursement Regulation
5.2 Reimbursement Process for Diagnosis
5.3 Reimbursement Process for Treatment

6. Methodology and Scope

Multiple Myeloma Therapeutics Market Segmentation

By Treatment

  • Chemotherapy
  • Immunotherapy
  • Targeted therapy
  • Radiation therapy
  • Stem cell transplant

By Distribution Channel

  • Hospitals
  • Retail
  • Online

By End User (Revenue, USD Bn):

  • Hospitals
  • Clinics
  • Cancer Research Centers

By Drug Class

Immunomodulatory drugs (IMiDs)

One of the most common therapies used to treat myeloma are immunomodulatory drugs, or IMiDs. These drugs work by modifying the immune system to attack myeloma cells and have been a significant advance in the treatment of multiple myeloma. Some of the commonly used IMiDs in multiple myeloma include:

  • Lenalidomide (Revlimid): Lenalidomide is an oral medication that is used in the treatment of multiple myeloma, as well as other blood cancers such as myelodysplastic syndromes (MDS). It may help the immune system in eliminating cancerous or abnormal blood cells. Moreover, it might stop the development of new blood vessels that tumours require to expand.
  • Pomalidomide (Pomalyst): Pomalidomide is an oral medication that is used to treat multiple myeloma. It works in a similar way to lenalidomide, by enhancing the immune system's ability to target cancer cells. Also, it makes it easier for immune cells to eliminate faulty myeloma cells, aiding in the production of healthy blood cells in the myeloma.
  • Thalidomide (Thalomid): Thalidomide was the first IMiD to be used in the treatment of multiple myeloma. It works by modulating the immune system and preventing the growth of blood vessels that supply the tumor
  • CC- 4047 (Actimid): CC-4047 is a newer IMiD that is still under investigation for the treatment of multiple myeloma. It works by inhibiting the growth of cancer cells and promoting their death.

Proteasome inhibitors

Proteasome inhibitors are a class of drugs that are commonly used in the treatment of multiple myeloma. They work by blocking the activity of proteasomes, which are cellular structures that break down proteins. This leads to the accumulation of proteins within the myeloma cells, ultimately causing their death. Some proteasome inhibitors used in multiple myeloma include:

  • Bortezomib (Velcade): Bortezomib was the first proteasome inhibitor approved for the treatment of multiple myeloma. It is given by injection and is often used in combination with other drugs, such as chemotherapy or immunomodulatory drugs. Bortezomib is highly effective in inducing remissions in newly diagnosed and relapsed/refractory multiple myeloma patients.
  • Carfilzomib (Kyprolis): Carfilzomib is a newer proteasome inhibitor that is approved for the treatment of multiple myeloma. It is given by injection and can be used as a single agent or in combination with other drugs. Carfilzomib has shown excellent results in heavily pretreated patients with relapsed/refractory multiple myeloma.
  • Ixazomib (Ninlaro): Ixazomib is an oral proteasome inhibitor that is approved for use in combination with lenalidomide and dexamethasone for the treatment of multiple myeloma. It is the first oral proteasome inhibitor and offers the convenience of home administration.

Monoclonal antibodies:

Monoclonal antibodies, target specific proteins on the surface of myeloma cells, causing them to be destroyed by the immune system. Some of the commonly used monoclonal antibodies in multiple myeloma include:

  • Daratumumab (Darzalex): Daratumumab is a monoclonal antibody that targets a protein called CD38, which is highly expressed on the surface of myeloma cells. By binding to CD38, daratumumab triggers the immune system to attack and destroy the cancer cells. It is approved for use in multiple myeloma in combination with other drugs, such as lenalidomide or bortezomib.
  • Elotuzumab (Empliciti): Elotuzumab is a monoclonal antibody that targets a protein called SLAMF7, which is also expressed on the surface of myeloma cells. By binding to SLAMF7, elotuzumab enhances the immune system's ability to attack the cancer cells. It is approved for use in combination with lenalidomide and dexamethasone for the treatment of multiple myeloma.
  • Isatuximab (Sarclisa): Isatuximab is a monoclonal antibody that targets a protein called CD38, similar to daratumumab. By binding to CD38, isatuximab triggers the immune system to attack and destroy the cancer cells. It is approved for use in combination with pomalidomide and dexamethasone for the treatment of multiple myeloma.

Chemotherapy drugs

Chemotherapy drugs work by killing rapidly dividing cells, including cancer cells. Chemotherapy is often used in combination with other drugs, such as steroids, immunomodulatory drugs, or proteasome inhibitors, to improve their effectiveness. Here are some chemotherapy drugs used in multiple myeloma:

  • Melphalan: Melphalan is an alkylating agent that is commonly used in the treatment of multiple myeloma. It is used as a preventative measure before having a stem cell transplant to treat multiple myeloma. It works by damaging the DNA of cancer cells, leading to their death. Melphalan is often used in combination with other drugs, such as prednisone, to treat newly diagnosed multiple myeloma.
  • Cyclophosphamide: Cyclophosphamide works by damaging the DNA of cancer cells, leading to their death. Cyclophosphamide is often used in combination with other drugs, such as dexamethasone, to treat relapsed or refractory multiple myeloma. Cyclophosphamide inhibits cancer cell proliferation, causing the body to kill the cancer cells.
  • Doxorubicin: Doxorubicin works by inhibiting the synthesis of DNA and RNA, leading to the death of cancer cells. Doxorubicin is often used in combination with other drugs, such as bortezomib or dexamethasone, to treat newly diagnosed or relapsed/refractory multiple myeloma. Doxorubicin belongs to the anthracycline class of chemotherapeutic drugs, which also includes daunorubicin, idarubicin, and epirubicin.
  • Etoposide: Etoposide is a topoisomerase inhibitor chemotherapy drug that is used in the treatment of multiple myeloma. It works by inhibiting the activity of topoisomerase enzymes, which are necessary for DNA replication and repair. Etoposide is often used in combination with other drugs, such as cisplatin, to treat relapsed or refractory multiple myeloma. It works by reducing or preventing cancer cell proliferation in your body.

Steroids

Steroids such as dexamethasone and prednisone are often used in combination with other drugs to treat multiple myeloma. They can reduce inflammation, suppress the immune system, and promote the death of myeloma cells.

  • Dexamethasone: Dexamethasone works by reducing inflammation and suppressing the immune system. Dexamethasone is often used in combination with other drugs to treat relapsed or refractory multiple myeloma.
  • Prednisone: Prednisone works by suppressing the immune system and reducing inflammation. Prednisone is often used in combination with other drugs, such as chemotherapy, to treat newly diagnosed multiple myeloma.
  • Methylprednisolone: Methylprednisolone is a steroid that is similar to prednisone and is also used in the treatment of multiple myeloma. It works by suppressing the immune system and reducing inflammation. Methylprednisolone is often used in combination with other drugs to treat relapsed or refractory multiple myeloma.

Steroids are effective in reducing inflammation and suppressing the immune system, which can help to control the growth of myeloma cells. However, they can have side effects, such as weight gain, mood changes, and increased risk of infection, so their use needs to be carefully monitored.

Others

Other drug classes used to treat multiple myeloma include:

  • Histone deacetylase inhibitors- A new class of cytostatic drugs that suppress tumour cell proliferation in vitro and in vivo by inducing cell cycle arrest, differentiation, and/or apoptosis
  • Immune checkpoint inhibitors- Checkpoint proteins are produced by some immune system cells, such as T cells, as well as some cancer cells. These checkpoints prevent too aggressive immune responses and, in some cases, prevent T cells from destroying cancer cells.
  • Targeted therapies- Proteasome inhibitors are one type of targeted therapy for multiple myeloma. Proteasome inhibitors include bortezomib (Velcade), carfilzomib (Kyprolis), and ixazomib (Ninlaro). They target proteasomes, which are enzymes that breakdown proteins in cells.

 

 

Insights10 will provide you with the reports within 10 key parameters which are:

  1. Market Overview
  2. Market Growth Drivers & Restraints
  3. Epidemiology of Disease Type
  4. Market Segmentation
  5. Market Share
  6. Competitive Landscape
  7. Key Company Profiles
  8. Healthcare Policies & Regulatory Framework
  9. Reimbursement Scenario
  10. Factors Driving Future Growth

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Last updated on: 27 September 2023
Updated by: Dhruv Joshi

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