Canada Primary Hyperoxaluria (PH) Drugs Market Analysis

Canada Primary Hyperoxaluria (PH) Drugs Market Analysis


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Canada Primary Hyperoxaluria (PH) Drugs Market is projected to grow from $xx Mn in 2023 to $xx Mn by 2030, registering a CAGR of xx% during the forecast period of 2023 ? 2030. Unmet Medical Need, Increasing Awareness and Diagnosis, Advancements in Research and Development, Growing Investment and Pipeline Development, Collaboration and Patient Advocacy,rise in the number of persons with the condition worldwide. The regulatory body's extension of special designations and rising consumer demand for medications including thiazide diuretics, calcium oxalate urinary inhibitors, and others to address a variety of health issues both contribute to the market's quick growth. Major global players in Primary Hyperoxaluria (PH) Drugs Market are Allena Pharmaceuticals, Inc., Intellia Drugs, Inc., OxThera, Dicerna Pharmaceuticals, Inc, Alnylam Pharmaceuticals, Inc., Pfizer Inc., and Sanofi.

ID: IN10CARD107 CATEGORY: Rare Diseases GEOGRAPHY: Canada AUTHOR: Sakshi Mantri

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Canada Primary Hyperoxaluria (PH) Drugs Market Analysis Summary

Canada Primary Hyperoxaluria (PH) Drugs Market is valued at around $1.4 Mn in 2022 and is projected to reach $2.73 Mn by 2030, exhibiting a CAGR of 8.7% during the forecast period 2023-2030.

Primary Hyperoxaluria (PH), a rare hereditary condition, is brought on by errors in the metabolism of glyoxylates, which build up oxalate mostly in the kidneys and result in end-stage renal failure. It can be divided into three categories based on the several genes involved: type 1 (AGXT) (PH-I), type 2 (GRHPR) (PH-II), and type 3 (HOGA1) (PH-III). Hematuria, urinary tract infections, and recurring kidney stones are possible symptoms (UTIs). In contrast to children, kidney stones are frequently the initial symptom of primary hyperoxaluria in adults. Other signs and symptoms include renal failure, chronic kidney disease, recurrent urinary tract infections, severe side discomfort, abdominal pain, and blood in the urine.

The treatment approach for Primary Hyperoxaluria involves various strategies, including dietary modifications, supportive care, and pharmacological interventions. The current treatment options include Lumasiran (Oxlumo) developed by alnylam Pharmaceuticals, which is a subcutaneously administered it is RNA interference (RNAi) medication for PH1 that has received FDA approval. It functions by concentrating on and preventing the synthesis of the oxalate-producing enzyme glycolate oxidase.

Dicerna's RNAi Therapeutic: Dicerna Pharmaceuticals is developing an investigational RNAi therapeutic, DCR-PHXC, for the treatment of PH1, PH2, and PH3. This therapy aims to reduce the production of glycolate oxidase or lactate dehydrogenase, enzymes involved in oxalate production, depending on the specific type of PH.

(ALLN-177) Reloxaliase developed by Allena Pharmaceuticals in this drug Oxalate is specifically broken down in the GI tract by the enzyme oxalate decarboxylase in ALLN-177, enabling the body to expel it through the stool. By preventing oxalate from building up in the body, this mechanism lessens the burden on the kidneys to filter and remove oxalate in the urine.

One of the key factors propelling the growth of the hyperoxaluria drug market is the rise in the number of persons with the condition worldwide. The regulatory body's extension of special designations and rising consumer demand for medications including thiazide diuretics, calcium oxalate urinary inhibitors, and others to address a variety of health issues both contribute to the market's quick growth. Major global players in Primary Hyperoxaluria (PH) Drugs Market are Allena Pharmaceuticals, Inc., Intellia Drugs, Inc., OxThera, Dicerna Pharmaceuticals, Inc, Alnylam Pharmaceuticals, Inc., Pfizer Inc., and Sanofi.

Market Dynamics

Market Drivers

The increase in people suffering from the disease globally is one of the major drivers of the primary hyperoxaluria medication market's growth. The growth in special designations from the regulatory body and growing demand for drugs such as calcium oxalate urinary inhibitors, thiazide diuretics, and others, for treating various illness problems, both contribute to the market's rapid expansion.

The development of technology that offers medicines for the particular treatment of the disease, the rise of acquisition strategies and corporate alliances for research efforts, and all of these have an effect on the market. The hyperoxaluria drug industry also benefits from growing public and private sector support, expanding disease-specific new therapeutic demand, and growing public awareness. The creation of novel treatment options also increases the market participants' possibilities of making money.

Market Restraints

On the other hand, market growth is likely to be constrained by the high cost of diagnosing and treating primary hyperoxaluria. Complex Disease Management, Reimbursement and Market Access issues. Due to the restricted operational revenue potential for targeted therapeutic research and development by many pharmaceutical companies, the primary hyperoxaluria medication business is predicted to experience difficulties.

Key players

Alexion Pharmaceuticals Kyowa Kirin Shire Grifols Kedrion Biopharma Octapharma Baxter International Takeda Pharmaceutical Company Pfizer Sanofi

1. Executive Summary
1.1 Disease Overview
1.2 Global Scenario
1.3 Country Overview
1.4 Healthcare Scenario in Country
1.5 Patient Journey
1.6 Health Insurance Coverage in Country
1.7 Active Pharmaceutical Ingredient (API)
1.8 Recent Developments in the Country

2. Market Size and Forecasting
2.1 Epidemiology of Disease
2.2 Market Size (With Excel & Methodology)
2.3 Market Segmentation (Check all Segments in Segmentation Section)

3. Market Dynamics
3.1 Market Drivers
3.2 Market Restraints

4. Competitive Landscape
4.1 Major Market Share

4.2 Key Company Profile (Check all Companies in the Summary Section)

4.2.1 Company
4.2.1.1 Overview
4.2.1.2 Product Applications and Services
4.2.1.3 Recent Developments
4.2.1.4 Partnerships Ecosystem
4.2.1.5 Financials (Based on Availability)

5. Reimbursement Scenario
5.1 Reimbursement Regulation
5.2 Reimbursement Process for Diagnosis
5.3 Reimbursement Process for Treatment

6. Methodology and Scope

Market Segmentations For Canada Primary Hyperoxaluria (PH) Drugs Market

By Treatment Type

  • Reloxaliase
  • Thiazide Diuretics
  • Supplements

By Drug Type:

  • Prescriptions
  • Over-the-counter drugs

By Population Type:

  • Children
  • Adults

Insights10 will provide you with the reports within 10 key parameters which are:

  1. Market Overview
  2. Market Growth Drivers & Restraints
  3. Epidemiology of Disease Type
  4. Market Segmentation
  5. Market Share
  6. Competitive Landscape
  7. Key Company Profiles
  8. Healthcare Policies & Regulatory Framework
  9. Reimbursement Scenario
  10. Factors Driving Future Growth

Based on our many years of experience, we believe that these are the parameters that are critical to decision-making for business stakeholders. Our focused approach to developing reports focused on 10 key parameters, enabled us to arrive at the name “Insights10”.

 

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Stage II: Market Data Analysis and Statistical Model

Market Trends: We generally look at macro parameters and micro indicators. The macro parameters include changes in government policies, demand and supply of the market, government intervention programs, and major market share. The micro indicators are GDP growth, market size, market volume, etc. We also understand nuances specific to each country like the US, Canada, India, Germany, etc., and have worked across 60+ countries and hence not only understand global trends but how these differ by country, how payment models, market structure, cultural parameters, etc. differ in each country.

Market Sizing and Analysis: Our expert data analytics team has created various market forecast models by employing the top-down approach i.e. starting with the large overall market and segmenting different areas and the bottom-up approach i.e. starting with population and epidemiology and rolling up based on spend, etc., estimating the size of the market, and distributing among the geographic and/or product segments.

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The study on the market covers the analysis of the leading geographies such as Asia-Pacific, Africa, Europe, Middle East, North America, and  Latin America for the period of 2022 to 2030. The qualitative analysis covers the industry landscape and trends, market opportunities, competitive landscape, and policy and regulatory scenario, and the quantitative analysis covers different market estimates and forecasts.

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We make sure to finalize the numbers in alignment with the market research. Firstly, our internal experts ensure thorough validation and checking to ensure accurate and precise analysis and then validation is also done using a multiple-data analysis model. Two-level validation is done and entails the finalization of the report scope and the way of representation pattern.

 

 

Stage III: Interpretation and Presentation

Analysis & Interpretation: The information gathered is then analyzed and synthesized. The second series of interviews are done if necessary to check and validate. The future opportunities are analyzed by understanding product commercialization and many other factors. It also comprises the analysis of data discrepancies observed across various data sources. Information procured from secondary and primary results is then, interpreted by considering the following parameters: (a partial list)

  • Establishing market drivers and trends
  • Analyzing the regulatory landscape to understand future growth
  • Market Segment based analysis to obtain revenue/volume
  • ​Analyzing current needs and determining penetration to estimate the market

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Data curated from the analysis and interpretation are drawn to portray all in one consolidated report.

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The foreign exchange rates are calculated on the respective dates and for the respective regions covered in the study.

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Last updated on: 04 July 2023
Updated by: Shivam Zalke

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